ENKTL Clinical Trials

Extranodal NK/T-cell lymphoma (ENKTL) is an EBV-associated lymphoma that most commonly presents in the nasal cavity and upper aerodigestive tract. Below are 100 curated trials that include ENKTL patients.

100

Total matches

11

Highest priority

75

Recruiting now

14

With US sites

12

Phase 3 trials

Showing 100 curated ENKTL trials

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Highest Priority — Landmark & Practice-Changing (11)

Phase 3 randomized trials with strong rationale.

Phase 3RecruitingPriority 1 · Highest priorityNCT06776952

A Randomized, Double-blind, Multicenter Phase III Study of XNW5004 Tablets in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma

This Phase 3 trial is comparing XNW5004 ; Chidamide placebo and XNW5004 placebo; Chidamide against other options for people whose T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Days to 70 Days years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Evopoint Biosciences Inc.

Treatment length

Ask the trial team for details

Phase 3Not yet recruitingPriority 1 · Highest priorityNCT05700448

Study of Sugemalimab (or Placebo) Plus PGemOx Regimen in Participants With Extranodal NK/T-Cell Lymphoma

This Phase 3 trial is comparing Sugemalimab, Placebo, and other medications against other options for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

CStone Pharmaceuticals

Treatment length

Ask the trial team for details

Phase 3RecruitingPriority 1 · Highest priorityNCT04365036

A Multicenter, Phase 3, Randomized Trial of Sequencial Chemoradiotherapy with or Without Toripalimab (PD-1 Antibody) in Newly Diagnosed Early-Stage Extranodal Natural Killer/T Cell Lymphoma, Nasal Type (ENKTL)

This Phase 3 trial is comparing different first-line treatment approaches for people newly diagnosed with NK/T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 3RecruitingPriority 1 · Highest priorityNCT05931263

A Randomized Clinical Trial Comparing Chi-BEAM With BEAM Regimen Combined With ASCT for the Treatment of ND PTCL

This Phase 3 trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 65 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

The First Affiliated Hospital with Nanjing Medical University

Treatment length

Ask the trial team for details

Phase 3RecruitingPriority 1 · Highest priorityNCT07234162

A Phase 3 Multinational Study of Golidocitinib Versus Investigator's Choice in r/r PTCL (JACKPOT19)

This Phase 3 trial is comparing Golidocitinib, Chidamide, and other medications against other options for people whose T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Dizal Pharmaceuticals

Treatment length

Ask the trial team for details

Phase 3Not yet recruitingPriority 1 · Highest priorityNCT06953739

A Study Comparing of P-GEMD Regimen Versus P-Gemox Regimen With Untreated Early-Stage NUAT or Advanced-Stage ENKTL.

This Phase 3 trial is comparing different first-line treatment approaches for people newly diagnosed with NK/T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

The First Affiliated Hospital with Nanjing Medical University

Treatment length

Ask the trial team for details

Phase 3RecruitingPriority 1 · Highest priorityNCT06072131

To Evaluate Efficacy of Belinostat or Pralatrexate in Combination Against CHOP Alone in PTCL

This Phase 3 trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 11 US locations across multiple states.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

11 US sites · California, Colorado, Florida +4

Sponsor

Acrotech Biopharma Inc.

Treatment length

Ask the trial team for details

Phase 3Not yet recruitingPriority 1 · Highest priorityNCT07639879

TR115 VS Investigator's Choice in Relapsed/Refractory Peripheral T/NK Cell Lymphoma

This Phase 3 trial is comparing TR115 and Investigator's Choice against other options for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Tarapeutics Science Inc.

Treatment length

Ask the trial team for details

Phase 3RecruitingPriority 1 · Highest priorityNCT07414758

Golidocitinib Versus Placebo as Maintenance Therapy in PTCL Patients With Response (CR/PR) After First-Line Chemotherapy

This Phase 3 trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Treatment length

Ask the trial team for details

Phase 3RecruitingPriority 1 · Highest priorityNCT06947967

Tucidinostat in Combination With CHOP in Newly Diagnosed Peripheral T-Cell Lymphoma With Follicular Helper of T Cell Phenotype

This Phase 3 trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 80 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Chipscreen Biosciences, Ltd.

Treatment length

Ask the trial team for details

Phase 3Not yet recruitingPriority 1 · Highest priorityNCT06255795

The Efficacy and Safety of Chidamide, Anti-PD-1 Antibody in Combination With Pegaspargase Versus DDGP in the Treatment of Newly Diagnosed, Stage III to IV Extranodal Natural Killer/T-Cell Lymphoma

This Phase 3 trial is comparing different first-line treatment approaches for people newly diagnosed with NK/T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 14 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

High Priority — Strong Clinical Rationale (14)

Important trials worth strongly considering.

Phase 1, Phase 2RecruitingPriority 2 · High priorityNCT05475925

A Study of DR-01 in Subjects With Large Granular Lymphocytic Leukemia or Cytotoxic Lymphomas

This Phase 1, Phase 2 trial is studying DR-01 for people with enteropathy-associated T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 15 US locations across multiple states.

Who it's for

  • Age 18 Years or older
  • See full trial listing for complete eligibility

Location

15 US sites · Alabama, California, Connecticut +8

Sponsor

Dren Bio

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 2 · High priorityNCT07180771

A Study of Bosmolisib (BR101801) in Participants With R/R PTCL.

This Phase 2 trial is testing BR101801 for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 19 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Boryung Pharmaceutical Co., Ltd

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 2 · High priorityNCT05934513

A Study of GFH009 Monotherapy in Patients with Relapsed or Refractory Peripheral T-cell Lymphoma (PTCL)

This Phase 1, Phase 2 trial is testing GFH009 for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Genfleet Therapeutics (Shanghai) Inc.

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 2 · High priorityNCT06909877

Study to Evaluate Efficacy and Safety of HH2853 in Relapsed/Refractory Peripheral T-cell Lymphoma

This Phase 1, Phase 2 trial is testing HH2853 Tablets for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Haihe Biopharma Co., Ltd.

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 2 · High priorityNCT05833724

Chidamide in Patients With Relapsed or Refractory Peripheral T-cell Lymphoma (R/R PTCL)

This Phase 2 trial is evaluating Chidamide as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 20 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Great Novel Therapeutics Biotech & Medicals Corporation

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 2 · High priorityNCT04747236

Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL

This Phase 2 trial is comparing Azacytidine, Romidepsin, and other medications against other options for people whose T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 6 US locations across multiple states.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

6 US sites · California, Connecticut, New York +3

Sponsor

University of Virginia

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 2 · High priorityNCT03922724

Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma

This Phase 2 trial is comparing ATL-RIC, mRIC, and other medications against other options for people whose T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 2 US locations.

Who it's for

  • Age 12 Years to 120 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

2 US sites · Maryland, Minnesota

Sponsor

National Cancer Institute (NCI)

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 2 · High priorityNCT07523555

Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies

This Phase 1, Phase 2 trial is comparing Autologous CD19/CD22 dual-target CAR-T module, Autologous CD19/CD20 dual-target CAR-T module, and other medications against other options for people whose T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Beijing Biotech

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 2 · High priorityNCT06630091

A Phase II, Single-center, Single-arm Study Evaluating the Safety and Efficacy of Golidocitinib in the Management of Newly Diagnosed Peripheral T Cell Lymphoma Patients (GOLDEN Study) and Correlative Study

This Phase 2 trial is evaluating Golidocitinib, Cyclophosphamide, and other medications as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. It is available at 1 US location.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

1 US site · Texas

Sponsor

M.D. Anderson Cancer Center

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 2 · High priorityNCT04068597

Study to Evaluate CCS1477 (Inobrodib) in Haematological Malignancies

This Phase 1, Phase 2 trial is comparing CCS1477, Pomalidomide, and other medications against other options for people whose T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 6 US locations across multiple states.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

6 US sites · Georgia, Indiana, Maryland +2

Sponsor

CellCentric Ltd.

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 2 · High priorityNCT05463263

A Phase 1/2 Study of STP938 (Dencatistat) for Adult Subjects With Relapsed/Refractory B-Cell and T-Cell Lymphomas

This Phase 1, Phase 2 trial is comparing STP938 against other options for people whose T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 3 US locations.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

3 US sites · Colorado, Florida, New York

Sponsor

Step Pharma, SAS

Treatment length

Ask the trial team for details

Phase 3RecruitingPriority 2 · High priorityNCT06122389

SHR2554 Clinical Study of Chidamide in the Treatment of T-cell Lymphoma

This Phase 3 trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Jiangsu HengRui Medicine Co., Ltd.

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 2 · High priorityNCT06702605

To Evaluate XNW5004 Tablets in Patients with Relapsed or Refractory Peripheral T Cell Lymphoma

This Phase 2 trial is testing XNW5004 tablets for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Evopoint Biosciences Inc.

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 2 · High priorityNCT06534060

MB-105 in Patients With CD5 Positive T-cell Lymphoma

This Phase 2 trial is testing Genetic: MB-105 for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. It is available at 12 US locations across multiple states.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

12 US sites · California, Colorado, Florida +8

Sponsor

March Biosciences Inc

Treatment length

Ask the trial team for details

Moderate Priority — Worth Discussing With Your Team (52)

Reasonable options worth a conversation.

Phase 1, Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07615283

Adebrelimab Combined With SHR2554 in Relapsed/Refractory PTCL and NK/T-Cell Lymphoma

This Phase 1, Phase 2 trial is testing Adebrelimab & SHR2554 for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT06583083

Sintilimab With P-GEMOX Versus the P-GEMOX in the Teatment of Advanced-stage Extranodal Natural Killer/T Cell Lymphoma

This Phase 2 trial is comparing different first-line treatment approaches for people newly diagnosed with NK/T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT06716658

JAK1 Inhibitor Golidocitnib for the Treatment of Relapsed/Refractory Indolent T/NK-cell Lymphomas

This Phase 2 trial is evaluating JAK1 Inhibitor as a treatment for people newly diagnosed with cutaneous T-cell lymphoma (skin lymphoma). The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Institute of Hematology & Blood Diseases Hospital, China

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT06824883

Sintilimab, Pegaspargase Plus GemOx for Untreated Extranodal NK/T-Cell Lymphoma

This Phase 2 trial is evaluating Immunochemotherapy as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Peking Union Medical College Hospital

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT07372352

Zeprumetostat, Azacitidine Combined With Lipo-MIT in R/R PTCL

This Phase 2 trial is evaluating Zeprumetostat, Azacitidine (AZA), and other medications as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

The First Affiliated Hospital of Soochow University

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT05963347

Go-CHOP as the Frontline Therapy for PTCL

This Phase 2 trial is evaluating Golidocitinib and CHOP Regimen as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Henan Cancer Hospital

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT05675813

Genotype-guided Treatment in Newly Diagnosed PTCL

This Phase 1, Phase 2 trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT04512534

Sintilimab Combined With Chidamide in Treating Peripheral T Cell Lymphoma

This Phase 2 trial is testing PD-1 antibody+ HDAC inhibitor for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Fudan University

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07385989

Golidocitinib Combined With P-GemOx Plus PD-1 Inhibitor Versus P-GemOx Plus PD-1 Inhibitor in First-Line Newly Diagnosed Advanced or Non-Nasal Extranodal NK/T-Cell Lymphoma

This Phase 2 trial is comparing different first-line treatment approaches for people newly diagnosed with NK/T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

WEI XU

Treatment length

Ask the trial team for details

Phase 1, Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07288814

Mitoxantrone Hydrochloride Liposome and Enlonstobart Combination Treatment in Patients With Relapsed or Refractory Peripheral T Cell Lymphoma (PTCL)

This Phase 1, Phase 2 trial is evaluating Mitoxantrone Hydrochloride Liposome & Enlonstobart as a treatment for people newly diagnosed with T-cell lymphoma. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Sun Yat-Sen University Cancer Center

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT07525466

Combination of Mitoxantrone Liposome and Etoposide, Dexamethasone, Pegaspargase and Golidocitinib (MEPL-G) in the Treatment of NK/T-cell Lymphoma Associated Hemophagocytic Lymphohistiocytosis (NKTCL-HLH)

This Phase 1, Phase 2 trial is studying Mitoxantrone liposome, Etoposide, and other medications for people with NK/T-cell lymphoma. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • See full trial listing for complete eligibility

Location

No US sites currently

Sponsor

Beijing Tongren Hospital

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT07000617

A Phase II Study of Dexamethasone, Azacitidine, Pegaspargase and Tislelizumab Plus Radiotherapy for Patients With Stage I/II Extranodal NK/T-cell Lymphoma

This Phase 2 trial is studying DAPT regimen plus radiotherapy for people with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Must be well enough for treatment (adequate performance status)

Location

No US sites currently

Sponsor

Peking University Cancer Hospital & Institute

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT06733051

Phase II Study of Golidocitinib and Benmelstobart in Patients with R/R ENKTL (JACKPOT50)

This Phase 2 trial is testing Golidocitinib and Benmelstobart for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT02859402

Allogeneic Stem Cell Transplantation in Relapsed/Refractory T-, NK/T-cell Lymphomas

This Phase 2 trial is evaluating Busulfan and Fludarabine as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 19 Years to 65 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Keimyung University Dongsan Medical Center

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07032532

Assessing An Oral JAK1 Inhibitor, Golidocitinib, in Patients Who Have Newly Diagnosed Peripheral T-Cell Lymphoma (JACKPOT23)

This Phase 2 trial is evaluating Golidocitinib and Golidocitinib plus CHOP as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 1, Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07209163

Combination Therapy With Tazemetostat in Relapsed and Refractory Peripheral T-cell Lymphoma

This Phase 1, Phase 2 trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT06855823

A Phase I/II Study of Golidocitinib Combined with Pomalidomide in R/R PTCL

This Phase 1, Phase 2 trial is testing Golicitinib combined with Pomadomide for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 80 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT06421948

Linperlisib Combined With Chidamide in Patients With PTCL

This Phase 1, Phase 2 trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 80 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Yanyan Liu

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT04922567

Efficacy and Safety of Lenalidomide Plus CHOP vs CHOP in Patients With Untreated Peripheral T-Cell Lymphoma

This Phase 2 trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT06739265

Golidocitinib Plus CHOP in Newly Diagnosed PTCL

This Phase 1, Phase 2 trial is evaluating Golidocitinib plus CHOP as a treatment for people newly diagnosed with T-cell lymphoma. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Peking Union Medical College Hospital

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT06160843

Pembrolizumab and Olaparib Treatment for Relapsed or Refractory Peripheral T-Cell Lymphoma

This Phase 2 trial is testing Pembrolizumab IV infusion Q3W and with daily oral Olaparib. for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 21 Years to 99 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

National Cancer Centre, Singapore

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT05976997

Prospective, Single Arm, Single Center Study of Duvelisib Combined With Chidamide in the Treatment of Newly Diagnosed Peripheral T-cell Lymphoma (PTCL)

This Phase 2 trial is evaluating Duvelisib and Chidamide as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Liling Zhang

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT07018752

A Platform Trial Evaluating New Drugs or Combination in R/R Peripheral T-cell Lymphomas

This Phase 1, Phase 2 trial is comparing roginolisib, golcadomide, and other medications against other options for people whose T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

The Lymphoma Academic Research Organisation

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT05949944

Linperlisib in Combination With CHOP in Previously Untreated Peripheral T-Cell Lymphoma

This Phase 1, Phase 2 trial is evaluating Linperlisib in combination with CHOP as a treatment for people newly diagnosed with T-cell lymphoma. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07554482

Selinexor Combined With Reduced-Dose Radiotherapy For Early-Stage Extranodal NK/T-Cell Lymphoma

This Phase 2 trial is studying Pegaspargase (PEG) Asparaginase, Gemcitabine (GEM), and other medications for people with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Must be well enough for treatment (adequate performance status)

Location

No US sites currently

Sponsor

Beijing Tongren Hospital

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07276698

Clinical Study on Maintenance Therapy With Selinexor Combined With Azacitidine After Allogeneic Hematopoietic Stem Cell Transplantation for NK/T-cell Lymphoma

This Phase 2 trial is testing Selinexor and azacitidine for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07457177

Phaes Ⅱ Study of Golidocitinib-Pegaspargase-PD-1 Antibody First-Line for Advanced ENKTL

This Phase 2 trial is evaluating Golidocitinib + Pegaspargase + Anti-PD-1 mAb as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

LIANG WANG

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07276737

Preconditioning With a Combination of Thiotepa, Cyclophosphamide, and Busulfan for Allogeneic Hematopoietic Stem Cell Transplantation in the Treatment of NK/T-Cell Lymphoma

This Phase 2 trial is evaluating Thiotepa as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Treatment length

Ask the trial team for details

Phase 2, Phase 3RecruitingPriority 3 · Moderate priorityNCT07389616

A Clinical Trial of Cidabenamine Plus Azacitidine to Prevent Post-Transplant Progression in High-Risk Peripheral T-Cell Lymphoma

This Phase 2, Phase 3 trial is testing Cidabenamine and Azacitidine for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT06966154

A Phase Ib/II Clinical Study Evaluating the Safety and Efficacy of Tislelizumab in Combination With Golidocitinib and Selinexor for the Treatment of R/R NKTCL

This Phase 1, Phase 2 trial is comparing tislezumab, golidocitinib, and other medications against other options for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Fudan University

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT06376721

Linperlisib Combined With Camrelizumab and Pegaspargase in Advanced or Relapsed/Refractory NK/T-cell Lymphoma

This Phase 1, Phase 2 trial is evaluating Linperlisib, Camrelizumab, and other medications as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Beijing Tongren Hospital

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07574528

A Phase II Study of Sintilimab, Pegaspargase and Selinexor Followed by Radiotherapy in Newly Diagnosed Stage I/II Extranodal NK/T-Cell Lymphoma

This Phase 2 trial is evaluating Sintilimab, Pegaspargase, and other medications as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT07380984

PD-1 Antibody-based Therapy With Concurrent RT for Early-stage NKTCL

This Phase 2 trial is comparing different first-line treatment approaches for people newly diagnosed with NK/T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT05833893

Clinical Study of XPO1 Inhibitor Selinexor Combined With COPL in Newly Diagnosed Advanced NK/T-cell Lymphoma

This Phase 2 trial is evaluating XPO1 inhibitor as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 14 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Chinese PLA General Hospital

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07279584

Golidocitinib Combined With GemOx in RR PTCL

This Phase 2 trial is testing golidocitinib and GEMOX for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

Phase 1, Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07139353

Linperlisib Combined With Chidamide in the Treatment of Relapsed or Refractory Peripheral T-cell Lymphoma

This Phase 1, Phase 2 trial is testing Linperlisib and Chidamide for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT07502768

Tislelizumab Plus Zeprumetostat for Relapsed or Refractory NK/T-Cell Lymphoma

This Phase 1, Phase 2 trial is comparing Tislelizumab and Zeprumetostat against other options for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Rong Tao

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT06314334

Screening Study of Combined Sequential Chemotherapy and Radiation Therapy for Early-stage NK/T-cell Lymphoma

This Phase 2 trial is studying Sintilimab+Pegaspargase, P-GemOx, and other medications for people with NK/T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Must be well enough for treatment (adequate performance status)

Location

No US sites currently

Sponsor

Fudan University

Treatment length

Ask the trial team for details

Phase 1, Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT06757387

Chidamide Plus Golidocitinib in Relapsed/Refractory Peripheral T-Cell Lymphoma

This Phase 1, Phase 2 trial is comparing chidamide and golidocitinib against other options for people whose T-cell lymphoma has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 80 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Peking University Cancer Hospital & Institute

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT07093710

Golidocitinib Combined With Mitoxantrone Hydrochloride Liposome or Chidamide in the Treatment of Relapsed or Refractory Peripheral T-cell Lymphoma

This Phase 1, Phase 2 trial is testing Golidocitinib, Mitoxantrone Hydrochloride Liposome, and other medications for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT06433362

CMOEP in the Treatment of Untreated Peripheral T-cell Lymphoma

This Phase 2 trial is evaluating CMOEP as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Tianjin Medical University Cancer Institute and Hospital

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT06151106

Chidamide and Duvalisibon for the Treatment of Refractory/Relapsed Peripheral T-cell Lymphoma

This Phase 2 trial is evaluating Chidamide combined with Duvillisib as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

The First Affiliated Hospital of Xiamen University

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT07628738

A Prospective Clinical Study on Reduced-intensity Radiotherapy for Stage I/II Low-risk Nasal-type NK/T-cell Lymphoma Achieving Complete Remission After Chemotherapy

This Phase 2 trial is studying reduced-intensity radiotherapy for people with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Must be well enough for treatment (adequate performance status)

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT06468267

RIC With Thiotepa Combined With Bu/Flu/Ara-C in Allo-HSCT for Relapsed or Refractory PTCL.

This Phase 2 trial is testing Thiotepa for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Xianmin Song, MD

Treatment length

Ask the trial team for details

Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07347288

SHR2554 as Maintenance Therapy in Patients With Peripheral T-cell Lymphoma

This Phase 2 trial is evaluating SHR2554 Tablets as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

The First Affiliated Hospital with Nanjing Medical University

Treatment length

Ask the trial team for details

Phase 1, Phase 2Not yet recruitingPriority 3 · Moderate priorityNCT07493330

Genotype-guided Targeted Agents Plus EZH2i for Primary Refractory PTCL

This Phase 1, Phase 2 trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT06176027

Azacytidine Plus CAOLD Regimen in Relapsed/Refractory Peripheral T-Cell Lymphomas

This Phase 1, Phase 2 trial is testing Azacytidine plus CAOLD regimen for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Navy General Hospital, Beijing

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT06519526

Exploratory Clinical Study of SHR-0302 and SHR-2554 in Patients With Relapsed/Refractory Peripheral T Cell Lymphoma

This Phase 2 trial is testing SHR-0302 and SHR-2554 for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Fudan University

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT05182957

Clinical Study on Anti-PD-1 Plus Lenalidomide and Azacitidine in Relapsed/Refractory Peripheral T-cell Lymphoma

This Phase 2 trial is evaluating Anti-PD-1 monoclonal antibody, Lenalidomide, and other medications as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

The First Affiliated Hospital of Soochow University

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT05477264

Concurrent Tislelizumab and Radiotherapy in Newly Diagnosed Extranodal NK/T-cell Lymphoma, Nasal Type

This Phase 2 trial is evaluating Tislelizumab as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 19 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Won Seog Kim

Treatment length

Ask the trial team for details

Phase 2RecruitingPriority 3 · Moderate priorityNCT05572983

Phase Ⅱ Study of Chidamide in Combination With CHOP in Previously Untreated Peripheral T-Cell Lymphoma With Follicular Helper of T Cell Phenotype

This Phase 2 trial is evaluating Chidamide combined with CHOP and Chidamide as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

Ask the trial team for details

Phase 1, Phase 2RecruitingPriority 3 · Moderate priorityNCT06420076

Sequential CAR-T Cells Therapy for CD5/CD7 Positive T-cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma Using CD5/CD7-Specific CAR-T Cells

This Phase 1, Phase 2 trial is testing CD5/CD7 CAR-T for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 2 Years to 90 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Essen Biotech

Treatment length

Ask the trial team for details

Lower Priority — Early-Stage or Limited Access (23)

Early-stage trials or limited site availability.

RecruitingPriority 4 · Lower priorityNCT05978141

A Registry for People With T-cell Lymphoma

This trial is studying Optional Blood Sample and Nail Sample for people with a type of T-cell lymphoma called AITL. The study measures how well this treatment works and monitors for side effects. It is widely available at 26 US locations.

Who it's for

  • See full trial listing for complete eligibility

Location

26 US sites · California, Colorado, Connecticut +12

Sponsor

Memorial Sloan Kettering Cancer Center

Treatment length

Ask the trial team for details

NARecruitingPriority 4 · Lower priorityNCT05444712

Transplantation After Complete Response In Patients With T-cell Lymphoma

This NA trial is comparing different first-line treatment approaches for people newly diagnosed with a type of T-cell lymphoma called AITL. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Hospices Civils de Lyon

Treatment length

Ask the trial team for details

Early Phase 1RecruitingPriority 4 · Lower priorityNCT07162012

Safety and Efficacy of Anti-EBV Autologous TCR-T Cell Injection in Relapsed/Refractory EBV-Positive Lymphoma

This Early Phase 1 trial is evaluating EBV TCR-T as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Treatment length

Ask the trial team for details

Early Phase 1RecruitingPriority 4 · Lower priorityNCT03719105

Chemoimmunotherapy and Allogeneic Stem Cell Transplant for NK T-cell Leukemia/Lymphoma

This Early Phase 1 trial is comparing different first-line treatment approaches for people newly diagnosed with anaplastic large cell lymphoma (ALCL). Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 6 US locations across multiple states.

Who it's for

  • Age 1 Year to 31 Years years
  • Newly diagnosed, not yet treated

Location

6 US sites · Alabama, California, Michigan +2

Sponsor

New York Medical College

Treatment length

Ask the trial team for details

Phase 1RecruitingPriority 4 · Lower priorityNCT06176690

Constitutive IL7R (C7R) Modified Banked Allogeneic CD30.CAR EBVSTS for CD30-Positive Lymphomas

This Phase 1 trial is testing C7R.CD30.CAR-EBVST cells for people whose ALK-negative ALCL has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. It is available at 2 US locations.

Who it's for

  • Age 12 Years to 75 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

2 US sites · Texas

Sponsor

Baylor College of Medicine

Treatment length

Ask the trial team for details

Not yet recruitingPriority 4 · Lower priorityNCT06963632

A Real-world Study on Golidocitinib-based Therapeutic Regimens for the Treatment of Patients With Peripheral T-cell Lymphoma

This trial is evaluating a new treatment as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

RecruitingPriority 4 · Lower priorityNCT03964480

Prospective Observational International Registry of Patients With Newly Diagnosed Peripheral T Cell Lymphoma.

This trial is evaluating a new treatment as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. It is available at 1 US location.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

1 US site · California

Sponsor

Associazione Angela Serra per la ricerca sul cancro

Treatment length

Ask the trial team for details

RecruitingPriority 4 · Lower priorityNCT07253129

Allo-HSCT Vs. Auto-HSCT for PTCL Patients With PR After First-line Systemic Therapy : A Prospective, Multicenter, Cohort Study-(T-START-PR)

This trial is evaluating Autologous Hematopoietic Stem Cell Transplantation and Allogenic stem cell transplant (ASCT) as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Treatment length

Ask the trial team for details

Phase 1Not yet recruitingPriority 4 · Lower priorityNCT06712173

Linperlisib Combined With EZH2 Inhibitor in Relapsed/Refractory Peripheral T-cell Lymphoma (PTCL)

This Phase 1 trial is testing linperlisib and SHR2554 for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Institute of Hematology & Blood Diseases Hospital, China

Treatment length

Ask the trial team for details

Phase 1RecruitingPriority 4 · Lower priorityNCT07164560

Exploratory Study of Umbilical Cord Blood-Derived CAR-NK Cell Therapy Targeting TRBC1/2 for Relapsed/Refractory T-Cell Lymphoma

This Phase 1 trial is testing Anti-TRBC1 CAR-T cells for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Treatment length

Ask the trial team for details

NARecruitingPriority 4 · Lower priorityNCT06069830

PET and EBV DNA-directed Therapy for Localized Nasal Extranodal NK/T Cell Lymphoma

This NA trial is evaluating 4 cycles of ESA regimen with sandwiched radiotherapy, 2 cycles of ESA regimen sequential radiotherapy and 2 cycles of PD-1 monoclonal antibody combined with pegaspargase, and other medications as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

NARecruitingPriority 4 · Lower priorityNCT05662540

PET/MR in the Staging and Efficacy Evaluation of Newly Diagnosed NK/T-cell Lymphoma

This NA trial is evaluating Positron Emission Tomography/Magnetic Resonance (PET/MR) as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 14 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

Not yet recruitingPriority 4 · Lower priorityNCT07657572

A Multi-center, Prospective, Registry Study to Analyze the Clinical Characteristics and Prognosis of Different Molecular Subtypes of Peripheral T-cell Lymphoma.

This trial is studying a new treatment for people with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • See full trial listing for complete eligibility

Location

No US sites currently

Sponsor

Ruijin Hospital

Treatment length

Ask the trial team for details

NARecruitingPriority 4 · Lower priorityNCT07072221

Bendamustine Combined With Chidamide and Lenalidomide for Relapsed and Refractory PTCL Patients

This NA trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

The First Affiliated Hospital of Soochow University

Treatment length

Ask the trial team for details

NARecruitingPriority 4 · Lower priorityNCT07074457

Chidamide Combined With Brentuximab Vedotin Regimen for CD30+ PTCL Patients

This NA trial is comparing different first-line treatment approaches for people newly diagnosed with T-cell lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

The First Affiliated Hospital of Soochow University

Treatment length

Ask the trial team for details

RecruitingPriority 4 · Lower priorityNCT07270861

Real-world Outcomes of Peripheral T-cell Lymphoma: A Multicenter Retrospective and Prospective Cohort Study

This trial is evaluating Observational as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Fudan University

Treatment length

Ask the trial team for details

NANot yet recruitingPriority 4 · Lower priorityNCT07542912

Sintilimab, Chidamide, and Azacitidine for Untreated Stage I-II Extranodal NK/T-Cell Lymphoma

This NA trial is evaluating SCA Induction followed by Response-Adapted Therapy as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

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Phase 1RecruitingPriority 4 · Lower priorityNCT04288726

Allogeneic CD30.CAR-EBVSTs in Patients With Relapsed or Refractory CD30-Positive Lymphomas

This Phase 1 trial is testing CD30.CAR-EBVST cells for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. It is available at 2 US locations.

Who it's for

  • Age 12 Years to 75 Years years
  • Lymphoma came back or did not respond to prior treatment

Location

2 US sites · Texas

Sponsor

Baylor College of Medicine

Treatment length

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Phase 1RecruitingPriority 4 · Lower priorityNCT05010005

A Study of Ruxolitinib and Duvelisib in People With Lymphoma

This Phase 1 trial is testing Ruxolitinib and Duvelisib for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. It is available at 9 US locations across multiple states.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

9 US sites · Florida, Massachusetts, New Jersey +1

Sponsor

Memorial Sloan Kettering Cancer Center

Treatment length

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Phase 1RecruitingPriority 4 · Lower priorityNCT06793956

Sintilimab and Linperlisib Combination Treatment in Relapsed or Refractory Extranodal Natural Killer/T Cell Lymphoma

This Phase 1 trial is testing Sintilimab and Linperlisib Combination Treatment for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Location

No US sites currently

Sponsor

Sun Yat-sen University

Treatment length

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RecruitingPriority 4 · Lower priorityNCT07353840

T Cell Lymphoma -Stratified Therapy After Response to First-line Treatment-CR

This trial is evaluating Autologous Hematopoietic Stem Cell Transplantation and Observation as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Treatment length

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RecruitingPriority 4 · Lower priorityNCT07470996

T Cell Lymphoma -Stratified Therapy After Response to First-line Treatment-NR

This trial is evaluating Allogenic stem cell transplant (ASCT) and Salvage Therapy as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Treatment length

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Early Phase 1RecruitingPriority 4 · Lower priorityNCT07598578

An Open-label, Single-arm, Multicenter Phase II Clinical Study of Azacitidine, Chidamide Combined With PD-1 Monoclonal Antibody in the Treatment of Refractory/Relapsed Peripheral T-cell Lymphoma.

This Early Phase 1 trial is evaluating Azacitidine (AZA) as a treatment for people newly diagnosed with T-cell lymphoma. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who it's for

  • Age 18 Years to 75 Years years
  • Newly diagnosed, not yet treated

Location

No US sites currently

Sponsor

Second Affiliated Hospital of Soochow University

Treatment length

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Other T-cell lymphoma subtypes