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Phase 2RecruitingPriority 3 · Moderate priorityNCT05833893

Clinical Study of XPO1 Inhibitor Selinexor Combined With COPL in Newly Diagnosed Advanced NK/T-cell Lymphoma

ClinicalTrials.gov

Plain-language summary

This Phase 2 trial is evaluating XPO1 inhibitor as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who can join (key eligibility)

  • Age 14 Years or older
  • Newly diagnosed, not yet treated
  • Must be well enough for treatment (adequate performance status)

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

XPO1 inhibitor (DRUG): COPL + XPO1 inhibitor (Selinexor, 60 mg, po., d1,8,15)

Drugs / treatments
XPO1 inhibitor
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Phase 2
Status
Recruiting
Design
Non-randomized, open-label
Enrollment target
10 patients
Primary endpoint
response rate; Incidence of Treatment-Emergent Adverse Events
Ages
14 Years to —
Start date
2023-05-01
Est. completion
2026-12-31

Locations

0 US sites · 1 total

No US sites currently listed.

Contact

Sponsor
Chinese PLA General Hospital (OTHER)
Contact
Yu Zhao, Graduate | zhaoyu301@126.com | 010-66937232

Tags

ENKTLNewly diagnosed
TrialCompass — Clinical Trial Summary

Clinical Study of XPO1 Inhibitor Selinexor Combined With COPL in Newly Diagnosed Advanced NK/T-cell Lymphoma

NCT05833893

Phase: Phase 2 | Status: Recruiting | Priority: Medium

Plain-language summary

This Phase 2 trial is evaluating XPO1 inhibitor as a treatment for people newly diagnosed with NK/T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who can join

  • Age 14 Years or older
  • Newly diagnosed, not yet treated
  • Must be well enough for treatment (adequate performance status)

What's being tested

XPO1 inhibitor (DRUG): COPL + XPO1 inhibitor (Selinexor, 60 mg, po., d1,8,15)

Drugs / treatments: XPO1 inhibitor

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Non-randomized, open-label

Enrollment target: 10 patients

Primary endpoint: response rate; Incidence of Treatment-Emergent Adverse Events

Ages: 14 Years to —

Start date: 2023-05-01 | Est. completion: 2026-12-31

Locations

0 US sites · 1 total

Contact

Yu Zhao, Graduate | zhaoyu301@126.com | 010-66937232

Sponsor: Chinese PLA General Hospital (OTHER)

Tags

ENKTL · Newly diagnosed

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT05833893

Prepared using TrialCompass (trialcompass.com) on June 19, 2026. For informational purposes only. Always discuss with your healthcare team.
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Data sourced from ClinicalTrials.gov.

For informational purposes only. Not medical advice — always consult your healthcare team.

Built with care for the rare cancer community.

Data last updated: June 2026

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