Adult T-Cell Leukemia/Lymphoma

This trial is testing stem cell transplant for patients with adult T-cell leukemia/lymphoma (ATLL), cutaneous T-cell lymphoma (CTCL), or T-cell prolymphocytic leukemia who have responded to prior therapy and may receive maintenance treatment. This is a Phase 2 trial, which means researchers are studying how well the treatment works and monitoring for side effects. Researchers want to learn whether this approach can help control the lymphoma. This trial is available at 1 location in the United States. The trial is currently recruiting patients.

This trial is testing Mogamulizumab for patients with adult T-cell leukemia/lymphoma (ATLL) or cutaneous T-cell lymphoma (CTCL) who have been newly diagnosed and have not yet received treatment as well as those whose disease has come back or stopped responding to prior treatment. This is a Phase 2 trial, which means researchers are studying how well the treatment works and monitoring for side effects. Researchers want to learn whether this approach can help control the lymphoma. This trial is available at 2 locations in the United States. The trial is currently recruiting patients.

This trial is testing Drug:5-ALA for patients with adult T-cell leukemia/lymphoma (ATLL) whose disease has come back or stopped responding to prior treatment. This is a Phase 1/2 trial, which means researchers are determining the best dose and getting early information about effectiveness. This trial does not currently have sites in the United States. The trial is currently recruiting patients.

This trial is testing a two-step haploidentical (half-matched) stem cell transplant using radiation-based reduced-intensity conditioning for patients with adult T-cell leukemia/lymphoma (ATLL) at various stages of their disease. This is a Phase 2 trial, which means researchers are studying how well the treatment works and monitoring for side effects. Patients are randomly assigned to different treatment groups. This trial is available at 1 location in the United States. The trial is currently recruiting patients.

This trial is testing Mogamulizumab for patients with adult T-cell leukemia/lymphoma (ATLL) at various stages of their disease. This is a Phase 2 trial, which means researchers are studying how well the treatment works and monitoring for side effects. Patients are randomly assigned to different treatment groups. This trial is available at 7 locations in the United States. The trial is currently recruiting patients.

This trial is testing Combination of Dolutegravir + Tenofovir DF for treatment of HTLV-1 infection for patients with adult T-cell leukemia/lymphoma (ATLL) at various stages of their disease. This is a Phase 2 trial, which means researchers are studying how well the treatment works and monitoring for side effects. Patients are randomly assigned to treatment groups, and neither patients nor doctors know which treatment is being given. This trial does not currently have sites in the United States. The trial is currently recruiting patients.

This is a research study collecting clinical information and/or biological samples from patients with angioimmunoblastic T-cell lymphoma (AITL) or TFH lymphomas, anaplastic large cell lymphoma (ALCL), adult T-cell leukemia/lymphoma (ATLL), cutaneous T-cell lymphoma (CTCL), enteropathy-associated T-cell lymphoma, extranodal NK/T-cell lymphoma, hepatosplenic T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma, peripheral T-cell lymphoma not otherwise specified (PTCL-NOS), subcutaneous panniculitis-like T-cell lymphoma, or T-cell prolymphocytic leukemia at various stages of their disease to advance understanding of these diseases and improve future treatments. No experimental treatment is given as part of this study. This trial is available at 26 locations in the United States.

This trial is testing allogeneic stem cell transplant (from a donor) for patients with adult T-cell leukemia/lymphoma (ATLL) or cutaneous T-cell lymphoma (CTCL) at various stages of their disease. Researchers want to learn whether this approach can help control the lymphoma. This trial is available at 1 location in the United States. The trial is currently recruiting patients.

This trial is testing Cyclophosphamide for patients with adult T-cell leukemia/lymphoma (ATLL) or cutaneous T-cell lymphoma (CTCL) whose disease has come back or stopped responding to prior treatment. This is a Phase 1 trial, which means researchers are finding the right dose and this is among the earliest testing in patients. This trial is available at 1 location in the United States. The trial is currently recruiting patients.

This trial is testing Cyclophosphamide for patients with adult T-cell leukemia/lymphoma (ATLL) who have been newly diagnosed and have not yet received treatment as well as those whose disease has come back or stopped responding to prior treatment. This is a Phase 1 trial, which means researchers are finding the right dose and this is among the earliest testing in patients. This trial is available at 19 locations in the United States. The trial is currently recruiting patients.