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Phase 2RecruitingPriority 2 · High priorityNCT06698003

A Study of Mogamulizumab to Prevent Adult T-cell Leukemia/Lymphoma in People With HTLV-1

ClinicalTrials.gov

Plain-language summary

This Phase 2 trial is studying Mogamulizumab for people with adult T-cell leukemia/lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 7 US locations across multiple states.

Who can join (key eligibility)

  • Age 18 Years or older
  • See full trial listing for complete eligibility

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

Mogamulizumab (DRUG): Cohort 1: 0.3 mg/kg of mogamulizumab every 12 weeks, for 2 total doses Cohort 2: 0.3 mg/kg of mogamulizumab every 6 weeks, for 4 total doses

Drugs / treatments
Mogamulizumab
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Phase 2
Status
Recruiting
Design
Non-randomized, open-label
Enrollment target
134 patients
Primary endpoint
Minimum dose and schedule of mogamulizumab to reduce the proviral load by ≥75%
Ages
18 Years to —
Start date
2024-11-15
Est. completion
2029-11-15

Locations

7 US sites · 7 total

New JerseyNew York

Contact

Sponsor
Memorial Sloan Kettering Cancer Center (OTHER)
Contact
Steven Horwitz, MD | horwitzs@MSKCC.ORG | 646-608-2680

Tags

ATLLany
TrialCompass — Clinical Trial Summary

A Study of Mogamulizumab to Prevent Adult T-cell Leukemia/Lymphoma in People With HTLV-1

NCT06698003

Phase: Phase 2 | Status: Recruiting | Priority: High

Plain-language summary

This Phase 2 trial is studying Mogamulizumab for people with adult T-cell leukemia/lymphoma. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 7 US locations across multiple states.

Who can join

  • Age 18 Years or older
  • See full trial listing for complete eligibility

What's being tested

Mogamulizumab (DRUG): Cohort 1: 0.3 mg/kg of mogamulizumab every 12 weeks, for 2 total doses Cohort 2: 0.3 mg/kg of mogamulizumab every 6 weeks, for 4 total doses

Drugs / treatments: Mogamulizumab

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Non-randomized, open-label

Enrollment target: 134 patients

Primary endpoint: Minimum dose and schedule of mogamulizumab to reduce the proviral load by ≥75%

Ages: 18 Years to —

Start date: 2024-11-15 | Est. completion: 2029-11-15

Locations

7 US sites · 7 total

New Jersey, New York

Contact

Steven Horwitz, MD | horwitzs@MSKCC.ORG | 646-608-2680

Sponsor: Memorial Sloan Kettering Cancer Center (OTHER)

Tags

ATLL · any

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT06698003

Prepared using TrialCompass (trialcompass.com) on June 19, 2026. For informational purposes only. Always discuss with your healthcare team.
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Data sourced from ClinicalTrials.gov.

For informational purposes only. Not medical advice — always consult your healthcare team.

Built with care for the rare cancer community.

Data last updated: June 2026

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