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Phase 1RecruitingPriority 4 · Lower priorityNCT06793956

Sintilimab and Linperlisib Combination Treatment in Relapsed or Refractory Extranodal Natural Killer/T Cell Lymphoma

ClinicalTrials.gov

Plain-language summary

This Phase 1 trial is testing Sintilimab and Linperlisib Combination Treatment for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who can join (key eligibility)

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

Sintilimab and Linperlisib Combination Treatment (DRUG): Sintilimab administered via intravenous infusion; Linperlisib administered orally.

Drugs / treatments
Sintilimab and Linperlisib Combination Treatment
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Phase 1
Status
Recruiting
Design
Non-randomized, open-label
Enrollment target
12 patients
Primary endpoint
DLT; RP2D
Ages
18 Years to —
Start date
2025-02-21
Est. completion
2030-01-31

Locations

0 US sites · 1 total

No US sites currently listed.

Contact

Sponsor
Sun Yat-sen University (OTHER)
Contact
Qingqing Cai, MD. PhD. | caiqq@sysucc.org.cn | 0086-20-87342823

Tags

ENKTLRelapsed/Refractory
TrialCompass — Clinical Trial Summary

Sintilimab and Linperlisib Combination Treatment in Relapsed or Refractory Extranodal Natural Killer/T Cell Lymphoma

NCT06793956

Phase: Phase 1 | Status: Recruiting | Priority: Lower

Plain-language summary

This Phase 1 trial is testing Sintilimab and Linperlisib Combination Treatment for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. The study starts with lower doses to find the safest effective dose before testing in more people. This trial does not currently list US sites.

Who can join

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)

What's being tested

Sintilimab and Linperlisib Combination Treatment (DRUG): Sintilimab administered via intravenous infusion; Linperlisib administered orally.

Drugs / treatments: Sintilimab and Linperlisib Combination Treatment

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Non-randomized, open-label

Enrollment target: 12 patients

Primary endpoint: DLT; RP2D

Ages: 18 Years to —

Start date: 2025-02-21 | Est. completion: 2030-01-31

Locations

0 US sites · 1 total

Contact

Qingqing Cai, MD. PhD. | caiqq@sysucc.org.cn | 0086-20-87342823

Sponsor: Sun Yat-sen University (OTHER)

Tags

ENKTL · Relapsed/Refractory

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT06793956

Prepared using TrialCompass (trialcompass.com) on June 19, 2026. For informational purposes only. Always discuss with your healthcare team.
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Data sourced from ClinicalTrials.gov.

For informational purposes only. Not medical advice — always consult your healthcare team.

Built with care for the rare cancer community.

Data last updated: June 2026

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