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Phase 2Not yet recruitingPriority 2 · High priorityNCT06573138

Selinexor, Anti-PD-1 Antibody Plus Golidocitinib in R/R NKTCL

ClinicalTrials.gov

Plain-language summary

This Phase 2 trial is testing Selinexor and anti-PD-1 antibody plus Golidocitinib for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who can join (key eligibility)

  • Age 14 Years to 75 Years years
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

Selinexor, anti-PD-1 antibody plus Golidocitinib (DRUG): Selinexor, 40mg, qw, po; anti-PD1 antibody, 200mg, d1, i.v. (21d cycle); Golidocitinib, Dose 1, 150mg, qod, po; Dose2, 150mg, qd, po.

Drugs / treatments
Selinexor, anti-PD-1 antibody plus Golidocitinib
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Phase 2
Status
Not yet recruiting
Design
Non-randomized, open-label
Enrollment target
18 patients
Primary endpoint
Best CRR
Ages
14 Years to 75 Years
Start date
2024-09-01
Est. completion
2027-07-01

Locations

0 US sites · 0 total

No US sites currently listed.

Contact

Sponsor
Ruijin Hospital (OTHER)
Contact
Weili Zhao, Prof. | zwl_trial@163.com | 008602164370045

Tags

ENKTLRelapsed/Refractory
TrialCompass — Clinical Trial Summary

Selinexor, Anti-PD-1 Antibody Plus Golidocitinib in R/R NKTCL

NCT06573138

Phase: Phase 2 | Status: Not yet recruiting | Priority: High

Plain-language summary

This Phase 2 trial is testing Selinexor and anti-PD-1 antibody plus Golidocitinib for people whose NK/T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who can join

  • Age 14 Years to 75 Years years
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)

What's being tested

Selinexor, anti-PD-1 antibody plus Golidocitinib (DRUG): Selinexor, 40mg, qw, po; anti-PD1 antibody, 200mg, d1, i.v. (21d cycle); Golidocitinib, Dose 1, 150mg, qod, po; Dose2, 150mg, qd, po.

Drugs / treatments: Selinexor, anti-PD-1 antibody plus Golidocitinib

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Non-randomized, open-label

Enrollment target: 18 patients

Primary endpoint: Best CRR

Ages: 14 Years to 75 Years

Start date: 2024-09-01 | Est. completion: 2027-07-01

Locations

0 US sites · 0 total

Contact

Weili Zhao, Prof. | zwl_trial@163.com | 008602164370045

Sponsor: Ruijin Hospital (OTHER)

Tags

ENKTL · Relapsed/Refractory

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT06573138

Prepared using TrialCompass (trialcompass.com) on July 4, 2026. For informational purposes only. Always discuss with your healthcare team.
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Data sourced from ClinicalTrials.gov.

For informational purposes only. Not medical advice — always consult your healthcare team.

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Data last updated: June 2026

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