Ruxolitinib in Combination With CHOP Chemotherapy for the Treatment of Untreated Nodal T-Follicular Helper Cell Lymphomas
Plain-language summary
This Phase 1 trial is evaluating Biospecimen Collection, Bone Marrow Aspiration, and other medications as a treatment for people newly diagnosed with a type of T-cell lymphoma called AITL. The study starts with lower doses to find the safest effective dose before testing in more people. It is available at 1 US location.
Who can join (key eligibility)
- Age 18 Years or older
- Newly diagnosed, not yet treated
- Must be well enough for treatment (adequate performance status)
- May require specific number of prior treatments
Final eligibility is determined by the trial team. This list is a starting point only.
What's being tested
Biospecimen Collection (PROCEDURE): Undergo blood sample collection | Bone Marrow Aspiration (PROCEDURE): Undergo bone marrow biopsy and aspiration | Bone Marrow Biopsy (PROCEDURE): Undergo bone marrow biopsy and aspiration | Computed Tomography (PROCEDURE): Undergo CT and FDG-PET/CT | Cyclophosphamide (DRUG): Given IV | Doxorubicin (DRUG): Given IV | Echocardiography Test (PROCEDURE): Undergo ECHO | FDG-Positron Emission Tomography (PROCEDURE): Undergo FDG-PET/CT | Filgrastim (BIOLOGICAL): Given SC | Fludeoxyglucose F-18 (OTHER): Given FDG | Multigated Acquisition Scan (PROCEDURE): Undergo MUGA | Pegfilgrastim (BIOLOGICAL): Given SC | Prednisone (DRUG): Given PO | Questionnaire Administration (OTHER): Ancillary studies | Ruxolitinib Phosphate (DRUG): Given PO | Vincristine (DRUG): Given IV
- Drugs / treatments
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy, Computed Tomography, Cyclophosphamide, Doxorubicin, Echocardiography Test, FDG-Positron Emission Tomography, Filgrastim, Fludeoxyglucose F-18, Multigated Acquisition Scan, Pegfilgrastim, Prednisone, Questionnaire Administration, Ruxolitinib Phosphate, Vincristine
- Treatment length
- Ask the trial team for details
- Visit frequency
- Ask the trial team for details