Ruxolitinib in Combination With CHOP Chemotherapy for the Treatment of Untreated Nodal T-Follicular Helper Cell Lymphomas
Plain-language summary
This trial is testing Cyclophosphamide for patients with angioimmunoblastic T-cell lymphoma (AITL) or TFH lymphomas or peripheral T-cell lymphoma not otherwise specified (PTCL-NOS) who have been newly diagnosed and have not yet received treatment. This is a Phase 1 trial, which means researchers are finding the right dose and this is among the earliest testing in patients. The study looks at both safety and how well the treatment controls the lymphoma. This trial is available at 1 location in the United States. The trial is currently recruiting patients.
Who can join (key eligibility)
- Age 18 Years or older
- Newly diagnosed, not yet treated
- Must be well enough for treatment (adequate performance status)
Final eligibility is determined by the trial team. This list is a starting point only.
What's being tested
Biospecimen Collection (PROCEDURE): Undergo blood sample collection | Bone Marrow Aspiration (PROCEDURE): Undergo bone marrow biopsy and aspiration | Bone Marrow Biopsy (PROCEDURE): Undergo bone marrow biopsy and aspiration | Computed Tomography (PROCEDURE): Undergo CT and FDG-PET/CT | Cyclophosphamide (DRUG): Given IV | Doxorubicin (DRUG): Given IV | Echocardiography Test (PROCEDURE): Undergo ECHO | FDG-Positron Emission Tomography (PROCEDURE): Undergo FDG-PET/CT | Filgrastim (BIOLOGICAL): Given SC | Fludeoxyglucose F-18 (OTHER): Given FDG | Multigated Acquisition Scan (PROCEDURE): Undergo MUGA | Pegfilgrastim (BIOLOGICAL): Given SC | Prednisone (DRUG): Given PO | Questionnaire Administration (OTHER): Ancillary studies | Ruxolitinib Phosphate (DRUG): Given PO | Vincristine (DRUG): Given IV
Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy, Computed Tomography, Cyclophosphamide, Doxorubicin, Echocardiography Test, FDG-Positron Emission Tomography, Filgrastim, Fludeoxyglucose F-18, Multigated Acquisition Scan, Pegfilgrastim, Prednisone, Questionnaire Administration, Ruxolitinib Phosphate, Vincristine
- Treatment length
- Ask the trial team for details
- Visit frequency
- Ask the trial team for details