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Phase 2RecruitingPriority 2 · High priorityNCT06756308

A Study of Enasidenib in People With T-Cell Lymphoma

ClinicalTrials.gov

Plain-language summary

This Phase 2 trial is testing Enasidenib and Rituximab for people whose a type of T-cell lymphoma called AITL has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. It is available at 8 US locations across multiple states.

Who can join (key eligibility)

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)
  • May require specific number of prior treatments

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

Enasidenib (DRUG): Enasidenib 100 mg daily on 28-day cycles. | Rituximab (DRUG): IV rituximab 375 mg/m² weekly for the first month, and monthly thereafter on 28-day cycles, for a total of four months of rituximab.

Drugs / treatments
Enasidenib, Rituximab
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Phase 2
Status
Recruiting
Design
Non-randomized, open-label
Enrollment target
25 patients
Primary endpoint
response rate
Ages
18 Years to —
Start date
2024-12-24
Est. completion
2027-12

Locations

8 US sites · 8 total

MassachusettsNew JerseyNew York

Contact

Sponsor
Memorial Sloan Kettering Cancer Center (OTHER)
Contact
Zachary Epstein-Peterson, MD | epsteinz@mskcc.org | 646-608-4176

Tags

AITL/TFHMaintenanceRelapsed/Refractory
TrialCompass — Clinical Trial Summary

A Study of Enasidenib in People With T-Cell Lymphoma

NCT06756308

Phase: Phase 2 | Status: Recruiting | Priority: High

Plain-language summary

This Phase 2 trial is testing Enasidenib and Rituximab for people whose a type of T-cell lymphoma called AITL has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. It is available at 8 US locations across multiple states.

Who can join

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)
  • May require specific number of prior treatments

What's being tested

Enasidenib (DRUG): Enasidenib 100 mg daily on 28-day cycles. | Rituximab (DRUG): IV rituximab 375 mg/m² weekly for the first month, and monthly thereafter on 28-day cycles, for a total of four months of rituximab.

Drugs / treatments: Enasidenib, Rituximab

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Non-randomized, open-label

Enrollment target: 25 patients

Primary endpoint: response rate

Ages: 18 Years to —

Start date: 2024-12-24 | Est. completion: 2027-12

Locations

8 US sites · 8 total

Massachusetts, New Jersey, New York

Contact

Zachary Epstein-Peterson, MD | epsteinz@mskcc.org | 646-608-4176

Sponsor: Memorial Sloan Kettering Cancer Center (OTHER)

Tags

AITL/TFH · Maintenance · Relapsed/Refractory

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT06756308

Prepared using TrialCompass (trialcompass.com) on June 19, 2026. For informational purposes only. Always discuss with your healthcare team.
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Data sourced from ClinicalTrials.gov.

For informational purposes only. Not medical advice — always consult your healthcare team.

Built with care for the rare cancer community.

Data last updated: June 2026

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