TrialCompass™ TCL
Find TrialsAI AssistantLetter GeneratorResourcesFAQAbout
Back to results
Phase 1RecruitingPriority 3 · Moderate priorityNCT06733441

A Study of TLN-254 in Participants With Relapsed or Refractory T-cell Lymphoma

ClinicalTrials.gov

Plain-language summary

This Phase 1 trial is comparing TLN-254 and TLN-254 against other options for people whose a type of T-cell lymphoma called AITL has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 4 US locations.

Who can join (key eligibility)

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

TLN-254 (DRUG): TLN-254 will be administered orally at a specified dose on specified days depending on treatment allocation. | TLN-254 (DRUG): TLN-254 will be administered orally at a specified dose on specified days.

Drugs / treatments
TLN-254, TLN-254
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Phase 1
Status
Recruiting
Design
Randomized, open-label
Enrollment target
50 patients
Primary endpoint
Percentage of Participants With Objective Response; Percentage of Participants With CR; Percentage of Participants With PR
Ages
18 Years to —
Start date
2024-12-16
Est. completion
2028-11-15

Locations

4 US sites · 5 total

CaliforniaMissouriNew YorkTennessee

Contact

Sponsor
Treeline Biosciences, Inc. (INDUSTRY)
Contact
Treeline Clinical Operations | clinicaloperations@treeline.bio | 857-228-0050

Tags

AITL/TFHALCLCTCLRelapsed/Refractory
TrialCompass — Clinical Trial Summary

A Study of TLN-254 in Participants With Relapsed or Refractory T-cell Lymphoma

NCT06733441

Phase: Phase 1 | Status: Recruiting | Priority: Medium

Plain-language summary

This Phase 1 trial is comparing TLN-254 and TLN-254 against other options for people whose a type of T-cell lymphoma called AITL has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 4 US locations.

Who can join

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)

What's being tested

TLN-254 (DRUG): TLN-254 will be administered orally at a specified dose on specified days depending on treatment allocation. | TLN-254 (DRUG): TLN-254 will be administered orally at a specified dose on specified days.

Drugs / treatments: TLN-254, TLN-254

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Randomized, open-label

Enrollment target: 50 patients

Primary endpoint: Percentage of Participants With Objective Response; Percentage of Participants With CR; Percentage of Participants With PR

Ages: 18 Years to —

Start date: 2024-12-16 | Est. completion: 2028-11-15

Locations

4 US sites · 5 total

California, Missouri, New York, Tennessee

Contact

Treeline Clinical Operations | clinicaloperations@treeline.bio | 857-228-0050

Sponsor: Treeline Biosciences, Inc. (INDUSTRY)

Tags

AITL/TFH · ALCL · CTCL · Relapsed/Refractory

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT06733441

Prepared using TrialCompass (trialcompass.com) on July 4, 2026. For informational purposes only. Always discuss with your healthcare team.
TrialCompass™

A free tool to help patients, caregivers, and clinicians find and understand clinical trials for T-cell lymphoma.

Explore

  • Find Trials
  • AI Assistant
  • Letter Generator
  • About
  • Share Your Feedback
  • Terms of Use
  • Privacy Policy

Data sourced from ClinicalTrials.gov.

For informational purposes only. Not medical advice — always consult your healthcare team.

Built with care for the rare cancer community.

Data last updated: June 2026

© 2026 TrialCompass™ TCL. All rights reserved.