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Phase 2RecruitingPriority 3 · Moderate priorityNCT06160843

Pembrolizumab and Olaparib Treatment for Relapsed or Refractory Peripheral T-Cell Lymphoma

ClinicalTrials.gov

Plain-language summary

This Phase 2 trial is testing Pembrolizumab IV infusion Q3W and with daily oral Olaparib. for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who can join (key eligibility)

  • Age 21 Years to 99 Years years
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)
  • May require specific number of prior treatments

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

Pembrolizumab IV infusion Q3W, with daily oral Olaparib. (DRUG): Pembrolizumab IV infusion 200 mg Q3W, with daily oral Olaparib 300mg BID, over a 3-week cycle.

Drugs / treatments
Pembrolizumab IV infusion Q3W, with daily oral Olaparib.
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Phase 2
Status
Recruiting
Design
Non-randomized, open-label
Enrollment target
24 patients
Primary endpoint
Objective Response Rates of treatment with Pembrolizumab plus Olaparib based on Cheson response criteria assessed by independent central review
Ages
21 Years to 99 Years
Start date
2024-07-01
Est. completion
2028-01

Locations

0 US sites · 1 total

No US sites currently listed.

Contact

Sponsor
National Cancer Centre, Singapore (OTHER)
Contact
Soon Thye LIM, MBBS, MRCP, Grad Dip (HM) | lim.soon.thye@singhealth.com.sg | +65 64368000

Tags

All T-cell lymphomasRelapsed/Refractory
TrialCompass — Clinical Trial Summary

Pembrolizumab and Olaparib Treatment for Relapsed or Refractory Peripheral T-Cell Lymphoma

NCT06160843

Phase: Phase 2 | Status: Recruiting | Priority: Medium

Plain-language summary

This Phase 2 trial is testing Pembrolizumab IV infusion Q3W and with daily oral Olaparib. for people whose T-cell lymphoma has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who can join

  • Age 21 Years to 99 Years years
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)
  • May require specific number of prior treatments

What's being tested

Pembrolizumab IV infusion Q3W, with daily oral Olaparib. (DRUG): Pembrolizumab IV infusion 200 mg Q3W, with daily oral Olaparib 300mg BID, over a 3-week cycle.

Drugs / treatments: Pembrolizumab IV infusion Q3W, with daily oral Olaparib.

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Non-randomized, open-label

Enrollment target: 24 patients

Primary endpoint: Objective Response Rates of treatment with Pembrolizumab plus Olaparib based on Cheson response criteria assessed by independent central review

Ages: 21 Years to 99 Years

Start date: 2024-07-01 | Est. completion: 2028-01

Locations

0 US sites · 1 total

Contact

Soon Thye LIM, MBBS, MRCP, Grad Dip (HM) | lim.soon.thye@singhealth.com.sg | +65 64368000

Sponsor: National Cancer Centre, Singapore (OTHER)

Tags

All T-cell lymphomas · Relapsed/Refractory

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT06160843

Prepared using TrialCompass (trialcompass.com) on June 19, 2026. For informational purposes only. Always discuss with your healthcare team.
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Data sourced from ClinicalTrials.gov.

For informational purposes only. Not medical advice — always consult your healthcare team.

Built with care for the rare cancer community.

Data last updated: June 2026

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