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Phase 2RecruitingPriority 3 · Moderate priorityNCT05976997

Prospective, Single Arm, Single Center Study of Duvelisib Combined With Chidamide in the Treatment of Newly Diagnosed Peripheral T-cell Lymphoma (PTCL)

ClinicalTrials.gov

Plain-language summary

This Phase 2 trial is evaluating Duvelisib and Chidamide as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who can join (key eligibility)

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated
  • Must be well enough for treatment (adequate performance status)

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

Duvelisib, Chidamide (DRUG): Duvelisib, 25mg, BID, PO; Chidamide, 20mg, BIW, PO;

Drugs / treatments
Duvelisib, Chidamide
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Phase 2
Status
Recruiting
Design
Non-randomized, open-label
Enrollment target
36 patients
Primary endpoint
Safety: Hematologic and non-hematologic toxicities (NCI CTCAE v5.0)
Ages
18 Years to 70 Years
Start date
2023-05-08
Est. completion
2026-12

Locations

0 US sites · 1 total

No US sites currently listed.

Contact

Sponsor
Liling Zhang (OTHER)
Contact
Liling Zhang, M.D | lily1228@sina.com | 0086 27 83262660

Tags

All T-cell lymphomasNewly diagnosed
TrialCompass — Clinical Trial Summary

Prospective, Single Arm, Single Center Study of Duvelisib Combined With Chidamide in the Treatment of Newly Diagnosed Peripheral T-cell Lymphoma (PTCL)

NCT05976997

Phase: Phase 2 | Status: Recruiting | Priority: Medium

Plain-language summary

This Phase 2 trial is evaluating Duvelisib and Chidamide as a treatment for people newly diagnosed with T-cell lymphoma. The study measures how well this treatment works and monitors for side effects. This trial does not currently list US sites.

Who can join

  • Age 18 Years to 70 Years years
  • Newly diagnosed, not yet treated
  • Must be well enough for treatment (adequate performance status)

What's being tested

Duvelisib, Chidamide (DRUG): Duvelisib, 25mg, BID, PO; Chidamide, 20mg, BIW, PO;

Drugs / treatments: Duvelisib, Chidamide

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Non-randomized, open-label

Enrollment target: 36 patients

Primary endpoint: Safety: Hematologic and non-hematologic toxicities (NCI CTCAE v5.0)

Ages: 18 Years to 70 Years

Start date: 2023-05-08 | Est. completion: 2026-12

Locations

0 US sites · 1 total

Contact

Liling Zhang, M.D | lily1228@sina.com | 0086 27 83262660

Sponsor: Liling Zhang (OTHER)

Tags

All T-cell lymphomas · Newly diagnosed

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT05976997

Prepared using TrialCompass (trialcompass.com) on June 19, 2026. For informational purposes only. Always discuss with your healthcare team.
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Data sourced from ClinicalTrials.gov.

For informational purposes only. Not medical advice — always consult your healthcare team.

Built with care for the rare cancer community.

Data last updated: June 2026

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