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Phase 2RecruitingPriority 2 · High priorityNCT05680558

Photopheresis in Early-stage Mycosis Fungoides

ClinicalTrials.gov

Plain-language summary

This Phase 2 trial is testing UVADEX® (methoxsalen) Sterile Solution in conjunction with the THERAKOS® CELLEX Photopheresis and THERAKOS® CELLEX photopheresis system for people whose cutaneous T-cell lymphoma (skin lymphoma) has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. It is available at 1 US location.

Who can join (key eligibility)

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

UVADEX® (methoxsalen) Sterile Solution in conjunction with the THERAKOS® CELLEX Photopheresis (DRUG): Extracorporeal Photopheresis (ECP) | THERAKOS® CELLEX photopheresis system (DEVICE): THERAKOS® CELLEX is an FDA-approved extra-corporeal photopheresis system

Drugs / treatments
UVADEX® (methoxsalen) Sterile Solution in conjunction with the THERAKOS® CELLEX Photopheresis, THERAKOS® CELLEX photopheresis system
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Phase 2
Status
Recruiting
Design
Non-randomized, open-label
Enrollment target
74 patients
Primary endpoint
Overall Response Rate
Ages
18 Years to —
Start date
2021-05-08
Est. completion
2028-07

Locations

1 US sites · 1 total

New York

Contact

Sponsor
Columbia University (OTHER)
Contact
Larisa Geskin, MD | ljg2145@cumc.columbia.edu | 212-305-5293

Tags

CTCLRelapsed/Refractory
TrialCompass — Clinical Trial Summary

Photopheresis in Early-stage Mycosis Fungoides

NCT05680558

Phase: Phase 2 | Status: Recruiting | Priority: High

Plain-language summary

This Phase 2 trial is testing UVADEX® (methoxsalen) Sterile Solution in conjunction with the THERAKOS® CELLEX Photopheresis and THERAKOS® CELLEX photopheresis system for people whose cutaneous T-cell lymphoma (skin lymphoma) has come back or has not responded to previous treatment. The study measures how well this treatment works and monitors for side effects. It is available at 1 US location.

Who can join

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment

What's being tested

UVADEX® (methoxsalen) Sterile Solution in conjunction with the THERAKOS® CELLEX Photopheresis (DRUG): Extracorporeal Photopheresis (ECP) | THERAKOS® CELLEX photopheresis system (DEVICE): THERAKOS® CELLEX is an FDA-approved extra-corporeal photopheresis system

Drugs / treatments: UVADEX® (methoxsalen) Sterile Solution in conjunction with the THERAKOS® CELLEX Photopheresis, THERAKOS® CELLEX photopheresis system

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Non-randomized, open-label

Enrollment target: 74 patients

Primary endpoint: Overall Response Rate

Ages: 18 Years to —

Start date: 2021-05-08 | Est. completion: 2028-07

Locations

1 US sites · 1 total

New York

Contact

Larisa Geskin, MD | ljg2145@cumc.columbia.edu | 212-305-5293

Sponsor: Columbia University (OTHER)

Tags

CTCL · Relapsed/Refractory

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT05680558

Prepared using TrialCompass (trialcompass.com) on June 19, 2026. For informational purposes only. Always discuss with your healthcare team.
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Data sourced from ClinicalTrials.gov.

For informational purposes only. Not medical advice — always consult your healthcare team.

Built with care for the rare cancer community.

Data last updated: June 2026

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