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Phase 1RecruitingPriority 4 · Lower priorityNCT05544968

Anti-CD30 biAb-AATC in Patients With Relapsed/Refractory CD30 Positive Hematopoietic Malignancies

ClinicalTrials.gov

Plain-language summary

This Phase 1 trial is comparing anti-CD30 Bispecific Antibody-armed anti-CD3-Activated Autologous T-cells (CD30 biAb-AATC) and GM-CSF against other options for people whose anaplastic large cell lymphoma (ALCL) has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 1 US location.

Who can join (key eligibility)

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

anti-CD30 Bispecific Antibody-armed anti-CD3-Activated Autologous T-cells (CD30 biAb-AATC) (DRUG): anti-CD30 Bispecific Antibody-armed anti-CD3-Activated Autologous T-cells | GM-CSF (DRUG): Hematopoietic agent that helps form white blood cells.

Drugs / treatments
anti-CD30 Bispecific Antibody-armed anti-CD3-Activated Autologous T-cells (CD30 biAb-AATC), GM-CSF
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Phase 1
Status
Recruiting
Design
Non-randomized, open-label
Enrollment target
42 patients
Primary endpoint
Maximum Tolerated Dose
Ages
18 Years to —
Start date
2026-03-04
Est. completion
2029-07

Locations

1 US sites · 1 total

Wisconsin

Contact

Sponsor
Medical College of Wisconsin (OTHER)
Contact
Medical College of Wisconsin Cancer Center Clinical Trials Office | cccto@mcw.edu | 866-680-0505

Tags

ALCLMaintenanceRelapsed/Refractory
TrialCompass — Clinical Trial Summary

Anti-CD30 biAb-AATC in Patients With Relapsed/Refractory CD30 Positive Hematopoietic Malignancies

NCT05544968

Phase: Phase 1 | Status: Recruiting | Priority: Lower

Plain-language summary

This Phase 1 trial is comparing anti-CD30 Bispecific Antibody-armed anti-CD3-Activated Autologous T-cells (CD30 biAb-AATC) and GM-CSF against other options for people whose anaplastic large cell lymphoma (ALCL) has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 1 US location.

Who can join

  • Age 18 Years or older
  • Lymphoma came back or did not respond to prior treatment
  • Must be well enough for treatment (adequate performance status)

What's being tested

anti-CD30 Bispecific Antibody-armed anti-CD3-Activated Autologous T-cells (CD30 biAb-AATC) (DRUG): anti-CD30 Bispecific Antibody-armed anti-CD3-Activated Autologous T-cells | GM-CSF (DRUG): Hematopoietic agent that helps form white blood cells.

Drugs / treatments: anti-CD30 Bispecific Antibody-armed anti-CD3-Activated Autologous T-cells (CD30 biAb-AATC), GM-CSF

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Non-randomized, open-label

Enrollment target: 42 patients

Primary endpoint: Maximum Tolerated Dose

Ages: 18 Years to —

Start date: 2026-03-04 | Est. completion: 2029-07

Locations

1 US sites · 1 total

Wisconsin

Contact

Medical College of Wisconsin Cancer Center Clinical Trials Office | cccto@mcw.edu | 866-680-0505

Sponsor: Medical College of Wisconsin (OTHER)

Tags

ALCL · Maintenance · Relapsed/Refractory

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT05544968

Prepared using TrialCompass (trialcompass.com) on June 19, 2026. For informational purposes only. Always discuss with your healthcare team.
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Data sourced from ClinicalTrials.gov.

For informational purposes only. Not medical advice — always consult your healthcare team.

Built with care for the rare cancer community.

Data last updated: June 2026

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