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RecruitingPriority 3 · Moderate priorityNCT05157581

Extracorporeal Photopheresis in Sezary Syndrome

ClinicalTrials.gov

Plain-language summary

This study is studying Extracorporeal photopheresis (ECP) and Methoxsalen Injection for people with cutaneous T-cell lymphoma (skin lymphoma). The study measures how well this treatment works and monitors for side effects. It is available at 3 US locations.

Who can join (key eligibility)

  • Age 18 Years to 100 Years years
  • See full trial listing for complete eligibility

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

Extracorporeal photopheresis (ECP) (DEVICE): Extracorporeal photopheresis is a process that exposes a collection of white blood cells and plasma to a light sensitizing agent, methoxsalen, and returns that compartment to the body. | Methoxsalen Injection (DRUG): Methoxsalen is a light-sensitizing sterile compound added to the collected white blood cells and plasma during ECP.

Drugs / treatments
Extracorporeal photopheresis (ECP), Methoxsalen Injection
Treatment length
Ask the trial team for details
Visit frequency
Ask the trial team for details

At a glance

Phase
Not applicable
Status
Recruiting
Design
Non-randomized, blind
Enrollment target
20 patients
Primary endpoint
Change from baseline in tumor-specific immunity; Change from baseline in tumor-specific immunity
Ages
18 Years to 100 Years
Start date
2023-04-04
Est. completion
2028-12

Locations

3 US sites · 3 total

GeorgiaMarylandPennsylvania

Contact

Sponsor
Oleg E. Akilov, MD, PhD (OTHER)
Contact
Charity Ruhl, LPN | ruhlcl@upmc.edu | 4126472013

Tags

CTCLany
TrialCompass — Clinical Trial Summary

Extracorporeal Photopheresis in Sezary Syndrome

NCT05157581

Status: Recruiting | Priority: Medium

Plain-language summary

This study is studying Extracorporeal photopheresis (ECP) and Methoxsalen Injection for people with cutaneous T-cell lymphoma (skin lymphoma). The study measures how well this treatment works and monitors for side effects. It is available at 3 US locations.

Who can join

  • Age 18 Years to 100 Years years
  • See full trial listing for complete eligibility

What's being tested

Extracorporeal photopheresis (ECP) (DEVICE): Extracorporeal photopheresis is a process that exposes a collection of white blood cells and plasma to a light sensitizing agent, methoxsalen, and returns that compartment to the body. | Methoxsalen Injection (DRUG): Methoxsalen is a light-sensitizing sterile compound added to the collected white blood cells and plasma during ECP.

Drugs / treatments: Extracorporeal photopheresis (ECP), Methoxsalen Injection

Treatment length: Ask the trial team for details

Visit frequency: Ask the trial team for details

Trial design

Non-randomized, blind

Enrollment target: 20 patients

Primary endpoint: Change from baseline in tumor-specific immunity; Change from baseline in tumor-specific immunity

Ages: 18 Years to 100 Years

Start date: 2023-04-04 | Est. completion: 2028-12

Locations

3 US sites · 3 total

Georgia, Maryland, Pennsylvania

Contact

Charity Ruhl, LPN | ruhlcl@upmc.edu | 4126472013

Sponsor: Oleg E. Akilov, MD, PhD (OTHER)

Tags

CTCL · any

View on ClinicalTrials.gov

https://clinicaltrials.gov/study/NCT05157581

Prepared using TrialCompass (trialcompass.com) on July 4, 2026. For informational purposes only. Always discuss with your healthcare team.
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Data sourced from ClinicalTrials.gov.

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Data last updated: June 2026

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