Plain-language summary

This Phase 2 trial is comparing Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, and other medications against other options for people whose anaplastic large cell lymphoma (ALCL) has come back or has not responded to previous treatment. Patients are randomly assigned to different treatment groups to see which approach works best. It is available at 1 US location.

Who can join (key eligibility)

• Age 6 Months or older
• Lymphoma came back or did not respond to prior treatment
• Must be well enough for treatment (adequate performance status)
• May require specific number of prior treatments

Final eligibility is determined by the trial team. This list is a starting point only.

What's being tested

Allogeneic Hematopoietic Stem Cell Transplantation (PROCEDURE): Undergo allogeneic hematopoietic stem cell transplantation | Cyclophosphamide (DRUG): Given IV | Cyclosporine (DRUG): Given IV or PO | Filgrastim (BIOLOGICAL): Given IV | Fludarabine (DRUG): Given IV | Mycophenolate Mofetil (DRUG): Given IV or PO | Mycophenolate Sodium (DRUG): Given PO | Total-Body Irradiation (RADIATION): Undergo total-body irradiation | Treosulfan (DRUG): Given IV | Bone Marrow Aspiration (PROCEDURE): Undergo bone marrow aspiration | Bone Marrow Biopsy (PROCEDURE): Undergo bone marrow biopsy | Echocardiography Test (PROCEDURE): Undergo echocardiography | Biospecimen Collection (PROCEDURE): Undergo blood sample collection | Computed Tomography (PROCEDURE): Undergo CT or PET/CT | Positron Emission Tomography (PROCEDURE): Undergo PET/CT

Drugs / treatments

Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Cyclosporine, Filgrastim, Fludarabine, Mycophenolate Mofetil, Mycophenolate Sodium, Total-Body Irradiation, Treosulfan, Bone Marrow Aspiration, Bone Marrow Biopsy, Echocardiography Test, Biospecimen Collection, Computed Tomography, Positron Emission Tomography

Treatment length

Ask the trial team for details

Visit frequency

Ask the trial team for details